Evogene Announces Completion of First-In-Class Foundation Model for Generative Molecule Design, Developed in Collaboration with Google Cloud
- 90% precision rate in novel molecule designs compared to 29% in traditional GPT AI models
- Built on extensive dataset of 38 billion molecular structures
- Enables simultaneous consideration of multiple complex product requirements
- Facilitates development of strong, defensible IP portfolios
- Version 2.0 already in development with enhanced capabilities
- None.
Insights
Evogene's new AI model dramatically improves precision in novel molecule design from 29% to 90%, potentially transforming pharmaceutical and agricultural product development.
Evogene has achieved a significant technological breakthrough with its new generative AI foundation model for small molecule design. The model addresses a fundamental challenge in both pharmaceutical and agricultural industries: discovering novel molecules that simultaneously satisfy multiple complex criteria. The most impressive technical achievement is the 90% precision in novel molecule design compared to just 29% in traditional GPT AI models.
What makes this development particularly valuable is the model's ability to optimize for multiple parameters simultaneously rather than sequentially. This represents a paradigm shift from traditional discovery methods that typically narrow options and reduce success probability by addressing challenges one after another. The foundation model was built on an impressive dataset of approximately 38 billion molecular structures and leverages Google Cloud's advanced AI infrastructure.
The strategic advantage here is two-fold: first, Evogene can now explore previously untapped areas of chemical space, creating truly novel molecular structures; second, this novelty translates directly to stronger intellectual property positions. For pharmaceutical applications, this means developing compounds with potentially higher efficacy and fewer side effects while maintaining patentability. For agricultural applications, this enables the creation of more effective and sustainable chemicals with robust IP protection.
The company is already developing version 2.0 with enhanced flexibility for multi-parameter optimization, suggesting a clear product roadmap and continued innovation. This technological advancement significantly strengthens Evogene's ChemPass AI tech-engine and potentially positions the company as a valuable partner for pharmaceutical and agricultural companies seeking more efficient R&D pathways.
The new model addresses the challenge of identifying novel small molecules that meet multiple product criteria, an essential requirement for pharma and agriculture applications
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In both pharma and agriculture, successful product development depends on identifying molecules that meet complex performance criteria while also being patentable. Traditional discovery methods typically address these challenges sequentially, a process that reduces success probability. In addition, they tend to steer towards well-explored or saturated areas of chemical space. This limits the potential for innovation, making it difficult to secure robust intellectual property and achieve meaningful product differentiation.
In contrast, generative AI models support companies in their small molecule discovery process by enabling the simultaneous consideration of multiple complex product requirements, all while creating truly novel molecular structures. This approach also facilitates the development of strong, defensible IP portfolios. Evogene's first-in-class foundation model is designed to do exactly that.
Developed in-house by Evogene's algorithm teams, this proprietary foundation model marks a dramatic advance over traditional generative AI. Internal computational analysis shows that it delivers approximately
Built on a large dataset of approximately 38 billion molecular structures, the model was trained and deployed using Google Cloud's advanced AI infrastructure, including high-performance GPUs and scalable storage. The result is a foundation model that not only powers Evogene's ChemPass AI today but will also provide a scalable base for future enhancements.
Ofer Haviv, President and CEO of Evogene, stated: "Completing our foundation model is a major milestone in our offering. It unlocks new frontiers for ChemPass AI, giving us the power to generate wholly novel molecules—ones that not only perform but also create new IP space. This is key to overcoming long-standing challenges in life-science R&D: from reducing late-stage failure in pharma to developing ag-chemicals that are effective, sustainable, and proprietary."
Boaz Maoz, Managing Director, Google Cloud Israel, commented: "We're pleased to collaborate with Evogene's innovation in AI-powered molecule design. Their progress with ChemPass AI highlights the strength of pairing advanced AI infrastructure with deep scientific insight. We look forward to seeing the impact of this new model in drug discovery and agriculture."
Evogene also announces that development is already underway on version 2.0 of its generative AI foundation model, with a focus on enhanced flexibility for multi-parameter optimization. The updated version will incorporate predefined, customized parameters tailored to therapeutic contexts or specific agriculture requirements. It will enable ChemPass AI to better balance complex real-world constraints, such as efficacy, toxicity, and stability, significantly improving its ability to generate molecules optimized for clinical, commercial, and regulatory success.
Evogene welcomes continued engagement with partners across the pharmaceutical and agriculture industries interested in accessing or integrating ChemPass AI for next-generation product development.
About Evogene Ltd.
Evogene Ltd. (NASDAQ: EVGN) (TASE: EVGN) is a computational biology company leveraging big data and artificial intelligence, aiming to revolutionize the development of life-science based products by utilizing cutting-edge technologies to increase the probability of success while reducing development time and cost.
Evogene established three unique tech-engines – MicroBoost AI, ChemPass AI and GeneRator AI. Each tech-engine is focused on the discovery and development of products based on one of the following core components: microbes (MicroBoost AI), small molecules (ChemPass AI), and genetic elements (GeneRator AI).
Evogene uses its tech-engines to develop products through strategic partnerships and collaborations, and its four subsidiaries including:
- Biomica Ltd. (www.biomicamed.com) – developing and advancing novel microbiome-based therapeutics to treat human disorders powered by MicroBoost AI;
- Lavie Bio (www.lavie-bio.com) – developing and commercially advancing, microbiome based ag-biologicals powered by MicroBoost AI;
- AgPlenus Ltd. (www.agplenus.com) – developing next generation ag-chemicals for effective and sustainable crop protection powered by ChemPass AI; and
- Casterra Ag (www.casterra.co) – developing and marketing superior castor seed varieties producing high yield and high-grade oil content, on an industrial scale for the biofuel and other industries powered by GeneRator AI.
For more information, please visit: www.evogene.com.
Forward-Looking Statements
This press release contains "forward-looking statements" relating to future events. These statements may be identified by words such as "may", "could", "expects", "hopes" "intends", "anticipates", "plans", "believes", "scheduled", "estimates", "demonstrates" or words of similar meaning. For example, Evogene and its subsidiaries are using forward-looking statements in this press release when it discusses the ability of the AI foundation model to identify novel small molecules that meet multiple complex product criteria while also being patentable, the ability of the AI foundation model to create highly potent, synthesizable, and patentable molecules across life-science products, the ability of the AI foundation model to reduce late-stage failure in pharma to and develop ag-chemicals that are effective, sustainable, and proprietary, and the development of version 2.0 of Evogene's generative AI foundation model, with a focus on enhanced flexibility for multi-parameter optimization. Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certain risks and uncertainties which are difficult to predict and are not guarantees of future performance. Therefore, actual future results, performance or achievements of Evogene and its subsidiaries may differ materially from what is expressed or implied by such forward-looking statements due to a variety of factors, many of which are beyond the control of Evogene and its subsidiaries, including, without limitation, the current war between
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